Surgical Robotics Technology

Accuray Showcases Radiation Therapy Innovations at ASTRO 2020

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Accuray Incorporated announced today that innovations in hardware and software solutions and clinical data presented at this year’s ASTRO (American Society for Radiation Oncology) Annual Meeting continue to support the use of the company’s CyberKnife® and TomoTherapy® platforms, including the next-generation Radixact® System, to deliver  (ultra) hypofractionated radiation treatments. Hypofractionated radiotherapy — a shorter course of radiotherapy with higher radiation doses per fraction — provides an efficient and effective treatment option for an increasing number of indications and may improve patients’ clinical and financial experiences.

New Standard in Radiation Treatment Delivery
With more than a decade of clinical proof behind Synchrony® Motion Synchronization and Real-Time Adaptive Radiotherapy Technology for the CyberKnife System, Accuray brought this advanced capability to the Radixact System. The artificial intelligence (AI)-driven Synchrony technology corrects for tumors that move as a result of bodily processes, including respiration and digestion, as well as patient movement, without uncomfortable patient restraints or breath-hold techniques, or human intervention. It is the only technology to use image guidance during radiation delivery to automatically adapt and synchronize radiation treatment in real-time with the movement of the tumor. Synchrony enables the medical care team to deliver high precision, (ultra) hypofractionated radiation treatments with confidence — knowing that treatment delivery will automatically account for target movement.

No Trade-Off Sub-Millimeter Precision and Accuracy
The CyberKnife S7™ System is the next-generation CyberKnife platform, a robotic, non-invasive radiation therapy device capable of treating cancerous and benign tumors throughout the body, as well as neurological disorders. The system was built from the ground-up to provide clinicians with the speed they need for operational efficiency, without sacrificing the precision and accuracy required for stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT). SRS and SBRT are advanced external beam radiation treatment techniques used to deliver (ultra) hypofractionated radiation therapy. The CyberKnife S7 System, with Synchrony and the VOLO™ Optimizer, facilitates the delivery of accurate, sub-millimeter, (ultra) hypofractionated treatments to tumors throughout the body, even to targets that move, in as little as 15 minutes.

Hypofractionated Treatments  a Proven Modality
Hypofractionated treatment regimens may expand medical care team options for achieving outstanding outcomes for a range of tumors. New data presented at ASTRO includes:

  • Prostate Cancer
    • CyberKnife customers pioneered prostate SBRT. Two studies confirmed the durability of the clinical response after 4- or 5-fraction CyberKnife SBRT in 640 early-stage prostate cancer patients followed for at least 10 years1,2.
  • Breast Cancer
    • Multiple studies reinforce the benefits of treating early stage breast cancer with TomoTherapy or CyberKnife for partial breast irradiation (PBI).
    • Three hundred and thirty-eight patients treated in 10 fractions delivered with the TomoTherapy System and followed for 72 months showed excellent long-term results with good to excellent cosmetic outcomes, reinforcing the role of the system in the treatment of early stage breast cancer3.
    • Two studies evaluating 5-fraction CyberKnife PBI and following patients for 36 months and 80 months, respectively, confirmed that treatment was well-tolerated and efficacious4,5. Moreover, for the first time at ASTRO, the preliminary results of a 1-fraction treatment delivered with the system were reported. The results for 19 patients are promising in terms of feasibility, cosmesis and early outcomes, potentially expanding the treatment options clinicians offer their patients6.

ClearRT™* Helical kVCT Imaging for the Radixact® System: Unveiled at ASTRO
The most recent innovation for the Radixact System, ClearRT Helical kVCT Imaging, is intended to quickly and cost-effectively produce clear, high-fidelity kVCT images that enhance soft-tissue visualization to improve cancer patients’ care. With the introduction of ClearRT for the Radixact System, Accuray is delivering on the full promise of the system’s unique helical architecture. The Radixact System is the only radiation therapy device with helical imaging, helical delivery, and intrafraction motion synchronization functionality using Synchrony®, providing expanded versatility and increased precision to treat the widest range of cases – from simple to the most complex – with the longest continuous imaging and treatment fields in the industry, up to 135 cm.

*ClearRT™ Helical kVCT Imaging for the Radixact Treatment Delivery System is 510(k) pending and is not available for sale in any market.

“We are pleased to have had the opportunity to present our latest innovations during this important meeting. Our radiation delivery systems and software solutions provide medical care teams with cutting-edge options for expanding the range of patients who may benefit from treatment. We continually invest in transforming what radiation therapy can do, with the goal of providing clinicians with more efficient and effective options that can handle even the most challenging cases, to get patients back to living their lives, faster,” said Suzanne Winter, chief commercial officer and senior vice president, R&D at Accuray.

1 D.B. Fuller, R.C. Chen et al. “10 Year Prostate Stereotactic Body Radiotherapy Outcomes: Relapse-free Survival, PSA Kinetics and Toxicity from a Pooled Analysis of Two Multi-institutional Trials.” ASTRO 2020 Poster Q&A Session. International Journal of Radiation Oncology*Biology*Physics Volume 108, Issue 3, Supplement, 1 November 2020, Pages e857-e858.
2 A.J. Katz, J. Kang. “Efficacy and Toxicity of Stereotactic Body Radiation Therapy for Localized Prostate Cancer: A Twelve-Year Study.” ASTRO 2020 Poster Q&A Session. International Journal of Radiation Oncology*Biology*Physics Volume 108, Issue 3, Supplement, 1 November 2020, Pages e870-e871.
3 U. de Paula, A.D. Andrulli et al. “Long-Term Outcomes of Once Daily Accelerated Partial Breast Irradiation with Tomotherapy: Phase II Trial Results on 338 Women Treated at a Single Institution.” ASTRO 2020 Poster Q&A Session. International Journal of Radiation Oncology*Biology*Physics Volume 108, Issue 3, Supplement, 1 November 2020, Page e16.
4 H.E. Morgan, D.N. Kim et al. “Three-Year Cosmetic Outcomes of a Phase I Dose Escalation Trial of 5-Fraction Stereotactic Partial Breast Irradiation for Early Stage Breast Cancer.” ASTRO 2020 Poster Q&A Session. International Journal of Radiation Oncology*Biology*Physics Volume 108, Issue 3, Supplement, 1 November 2020, Pages e15-e16.
5 J.A. Haas, M.R. Witten et al. “Stereotactic Body Radiation Therapy for Early-Stage Breast Cancer Using a Robotic Linear Accelerator-Longer Term Results from a Multi-Institutional Trial.” ASTRO 2020 Poster Q&A Session. International Journal of Radiation Oncology*Biology*Physics Volume 108, Issue 3, Supplement, 1 November 2020, Page e19.
6 A.S. Rahimi, D.N. Kim et al. “Multi-Institutional Trial of Phase I Dose Escalation Using Single Fraction Stereotactic Partial Breast Irradiation (S-PBI) for Early Stage Breast Cancer.” ASTRO 2020 Poster Q&A Session. International Journal of Radiation Oncology*Biology*Physics Volume 108, Issue 3, Supplement, 1 November 2020, Pages e19-e20.

SOURCE Accuray Incorporated

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